Fluminense beat Santa Fe 2-1. Best on the pitch was Caio Paulista, rated 7.7.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   BRA 4-2-3-1·4-2-3-1 COL
   Coach: Roger Machado · H. RiveraReferee: E. Aquino📍 Estadio Jornalista Mário Filho
2. 1. Second half
   2. 46'
      BRA
      Substitution
      ▲Gabriel Teixeira▼Luiz Henrique
   3. 46'
      COL
      Substitution
      ▲J. Pedroza▼Carlos Arboleda
   4. 56'
      BRA
      Yellow card
      Luccas Claro
   5. 58'
      COL
      GOOOAL!J. GonzálezAssist: C. Porras
   6. 60'
      BRA
      GOOOAL!FredAssist: Kayky
   7. 62'
      COL
      Yellow card
      A. Moralez
   8. 64'
      BRA
      Yellow card
      David Braz
   9. 67'
      BRA
      Substitution
      ▲J. Cazares▼Nenê
   10. 71'
       COL
       Substitution
       ▲J. Caballero▼Leonardo Pico
   11. 72'
       COL
       Substitution
       ▲Enrique Serje▼K. Osorio
   12. 74'
       BRA
       Substitution
       ▲Caio Paulista▼Kayky
   13. 77'
       BRA
       GOOOAL!Caio PaulistaAssist: J. Cazares
   14. 82'
       BRA
       Substitution
       ▲R. Bobadilla▼Fred
   15. 82'
       BRA
       Substitution
       ▲Wellington▼Martinelli
   16. 83'
       COL
       Substitution
       ▲J. Velásquez▼J. González
   17. 90+1'
       COL
       Substitution
       ▲H. McCormick▼Jhon Arias