Cerro Porteno beat Deportivo La Guaira 0-1. The winner had to work for it: 1 from 16 shots. Best on the pitch was C. Aquino, rated 7.9.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   VEN 5-4-1·4-4-1-1 PAR
   Coach: D. Farías · F. ArceReferee: F. Tello📍 Estadio Olímpico de la UCV
2. 1. First half
   2. 26'
      VEN
      Yellow card
      Y. Cumana
   3. 28'
      PAR
      GOOOAL!C. AquinoPenalty
   4. 40'
      PAR
      Yellow card
      R. Morales
   5. 43'
      PAR
      Yellow card
      MAMateus
3. 1. Second half
   2. 57'
      VEN
      Substitution
      ▲Carlos Cermeño▼A. Flores
   3. 66'
      VEN
      Substitution
      ▲J. Reyes▼D. Cure
   4. 66'
      VEN
      Substitution
      ▲Ronaldo Lucena▼F. Pol
   5. 74'
      PAR
      Substitution
      ▲E. Gimenez▼Mateus Gonçalves
   6. 74'
      PAR
      Substitution
      ▲Federico Carrizo▼M. Boselli
   7. 80'
      VEN
      Substitution
      ▲Á. Peña▼D. González
   8. 80'
      VEN
      Substitution
      ▲A. Ocanto▼C. Ortiz
   9. 85'
      PAR
      Substitution
      ▲F. Vera▼C. Aquino
   10. 90+1'
       VEN
       Yellow card
       Kendrys Silva
   11. 90+2'
       PAR
       Substitution
       ▲S. Bareiro▼R. Morales
   12. 90+3'
       VEN
       Yellow card
       A. Ocanto