Atletico Nacional and Club Nacional drew 0-0. Atletico Nacional controlled the ball — 62% possession — but had nothing to show for it. Club Nacional played with ten from minute 62. Best on the pitch was Y. Candelo, rated 8.2.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   COL 4-2-3-1·4-4-2 URU
   Coach: A. Guimarães · A. CapuccioReferee: D. Haro📍 Estadio Hernán Ramírez Villegas
2. 1. First half
   2. 7'
      URU
      Substitution
      ▲F. Píriz▼F. Carballo
   3. 33'
      COL
      Yellow card
      Y. Candelo
   4. 39'
      COL
      Yellow card
      Danovis Banguero
   5. 40'
      URU
      Yellow card
      Mathías Laborda
3. 1. Second half
   2. 46'
      COL
      Yellow card
      Y. Mosquera
   3. 59'
      URU
      Yellow card
      F. Píriz
   4. 62'
      URU
      Yellow card
      J. Trasante
   5. 62'
      URU
      Red card
      C. Cándido
   6. 63'
      URU
      Yellow card
      Gonzalo Bergessio
   7. 63'
      COL
      Yellow card
      J. Barrera
   8. 65'
      URU
      Substitution
      ▲G. Neves▼J. Trasante
   9. 65'
      URU
      Substitution
      ▲A. Oliveros▼G. Vega
   10. 68'
       COL
       Substitution
       ▲Alex Castro▼Y. Mosquera
   11. 76'
       COL
       Substitution
       ▲J. Duque▼J. Barrera
   12. 81'
       URU
       Substitution
       ▲A. Trezza▼Leandro Fernandez
   13. 87'
       URU
       Red card
       F. Carballo
   14. 89'
       COL
       Yellow card
       G. Perea
   15. 90+3'
       COL
       Substitution
       ▲N. Moreno▼Y. Candelo
   16. 90+4'
       URU
       Yellow card
       B. Ocampo