The Strongest beat Santos 2-1. Santos controlled the ball — 64% possession — but had nothing to show for it. The winner had to work for it: 2 from 16 shots. The Strongest played with ten from minute 24. Best on the pitch was Jean Mota, rated 8.2.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   BOL 5-3-2·4-2-3-1 BRA
   Coach: L. Orozco · Fernando DinizReferee: D. Haro📍 Estadio Hernando Siles
2. 1. First half
   2. 16'
      BOL
      GOOOAL!J. ReinosoAssist: R. Blackburn
   3. 17'
      BOL
      Yellow card
      G. Castillo
   4. 23'
      BOL
      GOOOAL!WillieAssist: R. Blackburn
   5. 24'
      BOL
      Yellow card
      G. Castillo
   6. 24'
      BOL
      Red card
      G. Castillo
   7. 26'
      BRA
      Yellow card
      Jean Mota
3. 1. Second half
   2. 46'
      BRA
      Substitution
      ▲Marcos Leonardo▼Gabriel Pirani
   3. 46'
      BRA
      Substitution
      ▲Jonathan Copete▼Kaiky
   4. 51'
      BRA
      Yellow card
      Kaio Jorge
   5. 60'
      BRA
      Yellow card
      Jonathan Copete
   6. 62'
      BRA
      Yellow card
      Felipe Jonatan
   7. 64'
      BRA
      GOOOAL!Felipe Jonatan
   8. 67'
      BOL
      Substitution
      ▲Jaime Arrascaita▼Willie
   9. 68'
      BOL
      Red card
      M. Zoch
   10. 73'
       BOL
       Yellow card
       J. Valverde
   11. 73'
       BRA
       Substitution
       ▲Allanzinho▼Ângelo
   12. 77'
       BRA
       Substitution
       ▲Madson▼Pará
   13. 78'
       BOL
       Substitution
       ▲Jesús Sagredo▼Rolando Blackburn
   14. 81'
       BRA
       Substitution
       ▲Ivonei▼Jean Mota
   15. 90+7'
       BOL
       Substitution
       ▲Marvin Bejarano▼J. Sagredo