Vélez Sarsfield beat Union La Calera 2-1. The winner had to work for it: 2 from 13 shots. Best on the pitch was Federico Mancuello, rated 7.9.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   ARG 4-2-3-1·4-3-1-2 CHI
   Coach: M. Pellegrino · L. MarcogiuseppeReferee: D. López📍 Estadio José Amalfitani
2. 1. First half
   2. 2'
      ARG
      GOOOAL!Cristian TarragonaAssist: L. Janson
   3. 5'
      CHI
      GOOOAL!Jeisson Vargas
   4. 35'
      CHI
      Yellow card
      Gonzalo Castellani
   5. 37'
      CHI
      Yellow card
      M. Cavalleri
   6. 39'
      ARG
      GOOOAL!Thiago AlmadaAssist: F. Ortega
3. 1. Second half
   2. 46'
      CHI
      Substitution
      ▲Matías Laba▼Gonzalo Castellani
   3. 46'
      CHI
      Substitution
      ▲Y. Oyanedel▼M. Cavalleri
   4. 61'
      CHI
      Yellow card
      A. Martínez
   5. 61'
      CHI
      Substitution
      ▲A. Vilches▼S. Ramírez
   6. 66'
      CHI
      Substitution
      ▲M. Fernandez▼E. Valencia
   7. 67'
      ARG
      Substitution
      ▲P. Galdames▼Federico Mancuello
   8. 72'
      ARG
      Yellow card
      A. Bouzat
   9. 72'
      ARG
      Substitution
      ▲M. Brizuela▼A. Bouzat
   10. 72'
       ARG
       Substitution
       ▲R. Centurión▼Thiago Almada
   11. 73'
       CHI
       Yellow card
       E. Wiemberg
   12. 75'
       CHI
       Substitution
       ▲B. Liuzzi▼A. Martínez
   13. 83'
       CHI
       Yellow card
       Matías Laba
   14. 88'
       ARG
       Substitution
       ▲G. Poblete▼S. Cáseres
   15. 88'
       ARG
       Substitution
       ▲L. Orellano▼L. Janson
   16. 90+4'
       ARG
       Yellow card
       G. Poblete