River Plate beat Santa Fe 2-1. Santa Fe controlled the ball — 70% possession — but had nothing to show for it. Best on the pitch was Leonardo Pico, rated 8.0.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   ARG 3-5-2·3-3-3-1 COL
   Coach: M. Gallardo · H. RiveraReferee: V. Carrillo📍 Estadio Monumental Antonio Vespucio Liberti
2. 1. First half
   2. 3'
      ARG
      GOOOAL!F. Angileri
   3. 6'
      ARG
      GOOOAL!Julián ÁlvarezAssist: H. Martínez
3. 1. Second half
   2. 46'
      COL
      Substitution
      ▲Diego Valdes▼J. Velásquez
   3. 46'
      COL
      Substitution
      ▲K. Osorio▼J. González
   4. 60'
      COL
      Yellow card
      K. Osorio
   5. 61'
      COL
      Substitution
      ▲S. Cárdenas▼D. Giraldo
   6. 64'
      COL
      Yellow card
      Jorge Ramos
   7. 73'
      COL
      GOOOAL!K. OsorioAssist: J. Arias
   8. 83'
      COL
      Yellow card
      A. Moralez
   9. 86'
      COL
      Substitution
      ▲A. Oliveros▼S. Cárdenas
   10. 86'
       COL
       Substitution
       ▲H. McCormick▼Jorge Ramos