Cerro Porteno beat America de Cali 1-0. America de Cali controlled the ball — 64% possession — but had nothing to show for it. Best on the pitch was S. Moreno, rated 7.7.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   PAR 4-4-1-1·4-3-3 COL
   Coach: F. Arce · J. GonzálezReferee: N. Pitana📍 Estadio General Pablo Rojas
2. 1. First half
   2. 5'
      PAR
      GOOOAL!E. GimenezAssist: R. Morales
   3. 45'
      PAR
      Yellow card
      W. Viera
3. 1. Second half
   2. 56'
      COL
      Yellow card
      H. Quiñónes
   3. 58'
      COL
      Yellow card
      L. Paz
   4. 65'
      COL
      Substitution
      ▲D. Vergara▼Y. Cabrera
   5. 68'
      PAR
      Yellow card
      J. Patiño
   6. 75'
      PAR
      Substitution
      ▲A. Maíz▼M. Boselli
   7. 75'
      PAR
      Substitution
      ▲A. Rodríguez▼W. Viera
   8. 75'
      COL
      Substitution
      ▲D. Cambindo▼Jeison Lucumí
   9. 75'
      COL
      Substitution
      ▲L. Sánchez▼L. Paz
   10. 82'
       PAR
       Substitution
       ▲S. Bareiro▼R. Morales
   11. 86'
       COL
       Substitution
       ▲J. Rodríguez▼L. Sánchez
   12. 88'
       PAR
       Substitution
       ▲P. Adorno▼C. Aquino