Boca Juniors beat The Strongest 3-0. Best on the pitch was Frank Fabra, rated 7.9.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   ARG 5-3-2·3-1-4-2 BOL
   Coach: M. Russo · L. OrozcoReferee: R. Tobar📍 Estadio Alberto José Armando
2. 1. First half
   2. 3'
      ARG
      GOOOAL!Agustín Almendra
   3. 20'
      ARG
      Yellow card
      Agustín Almendra
   4. 32'
      ARG
      Substitution
      ▲J. Campuzano▼Agustín Almendra
   5. 38'
      ARG
      Yellow card
      Edwin Cardona
   6. 44'
      ARG
      GOOOAL!S. VillaAssist: F. Fabra
3. 1. Second half
   2. 48'
      BOL
      Yellow card
      David Mateos
   3. 56'
      BOL
      Own goalJ. Valverde
   4. 64'
      BOL
      Substitution
      ▲Jaime Arrascaita▼Rolando Blackburn
   5. 69'
      ARG
      Substitution
      ▲Gonzalo Maroni▼Edwin Cardona
   6. 70'
      ARG
      Substitution
      ▲Julio Buffarini▼Nicolás Capaldo
   7. 70'
      ARG
      Substitution
      ▲L. Vázquez▼Carlos Tévez
   8. 70'
      ARG
      Substitution
      ▲C. Pavón▼S. Villa
   9. 81'
      BOL
      Substitution
      ▲Jesús Sagredo▼David Mateos
   10. 81'
       BOL
       Substitution
       ▲R. Castro▼Willie
   11. 90'
       BOL
       Substitution
       ▲D. Wayar▼R. Gomez Miranda
   12. 90+1'
       BOL
       Substitution
       ▲Rudy Cardozo▼R. Vaca