Club Nacional beat Argentinos Juniors 2-0. Argentinos Juniors controlled the ball — 65% possession — but had nothing to show for it. The winner had to work for it: 2 from 13 shots. Best on the pitch was B. Ocampo, rated 8.9.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   URU 4-4-1-1·3-5-2 ARG
   Coach: A. Capuccio · G. MilitoReferee: E. Aquino📍 Estadio Gran Parque Central
2. 1. Second half
   2. 60'
      ARG
      Yellow card
      C. Quintana
   3. 61'
      ARG
      Substitution
      ▲G. Carabajal▼G. Florentin
   4. 62'
      ARG
      Substitution
      ▲M. Coronel▼E. Herrera
   5. 63'
      URU
      Yellow card
      G. Neves
   6. 66'
      ARG
      Substitution
      ▲Elías Gómez▼C. Quintana
   7. 69'
      URU
      Substitution
      ▲A. D'Alessandro▼A. Trezza
   8. 72'
      ARG
      Substitution
      ▲Gabriel Ávalos▼J. Cabrera
   9. 72'
      ARG
      Substitution
      ▲F. Mater▼M. Romero
   10. 73'
       URU
       GOOOAL!Gonzalo BergessioAssist: B. Ocampo
   11. 75'
       URU
       Substitution
       ▲Á. Gabrielli▼A. Mendez
   12. 84'
       URU
       GOOOAL!B. Ocampo
   13. 85'
       URU
       Substitution
       ▲Rafael García▼G. Neves
   14. 85'
       URU
       Substitution
       ▲Ignacio Lores▼B. Ocampo
   15. 90+1'
       URU
       Yellow card
       Gonzalo Bergessio
   16. 90+1'
       ARG
       Yellow card
       K. Mac Allister