Defensa y Justicia and Independiente del Valle drew 1-1. Best on the pitch was B. Romero, rated 7.7.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2021
   ARG 4-1-4-1·3-4-1-2 ECU
   Coach: S. Beccacece · Renato PaivaReferee: Edina Alves Batista📍 Estadio Norberto Tito Tomaghello
2. 1. First half
   2. 11'
      ECU
      GOOOAL!J. EscobarAssist: E. Mera
   3. 36'
      ARG
      GOOOAL!B. RomeroAssist: E. Fernández
3. 1. Second half
   2. 58'
      ECU
      Substitution
      ▲B. García▼L. Faravelli
   3. 58'
      ECU
      Substitution
      ▲C. Ortiz▼B. Montenegro
   4. 58'
      ECU
      Substitution
      ▲N. Previtali▼C. Pellerano
   5. 63'
      ECU
      Substitution
      ▲J. Sánchez▼Jhoanner Chavez
   6. 65'
      ECU
      Yellow card
      C. Ortiz
   7. 65'
      ARG
      Substitution
      ▲Miguel Merentiel▼T. Martínez
   8. 65'
      ARG
      Substitution
      ▲L. T. Escalante▼C. Rius
   9. 74'
      ECU
      Substitution
      ▲P. Vite▼J. Escobar
   10. 83'
       ARG
       Substitution
       ▲V. Larralde▼Enzo Fernández
   11. 89'
       ARG
       Substitution
       ▲F. Paredes▼M. Rodríguez