Plaza Colonia beat The Strongest 2-0. The winner had to work for it: 2 from 25 shots. The Strongest played with ten from minute 33. J. Mascia scored 2 goals. Best on the pitch was J. Mascia, rated 8.9.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2022
   URU 4-4-2·3-5-1-1 BOL
   Coach: E. Espinel · C. DíazReferee: Bruno Arleu de Araujo📍 Estadio Centenario
2. 1. First half
   2. 19'
      URU
      GOOOAL!J. Mascia
   3. 20'
      URU
      Yellow card
      N. Dibble
   4. 33'
      BOL
      Yellow card
      D. Wayar
   5. 33'
      BOL
      Red card
      G. Esparza
   6. 37'
      BOL
      Yellow card
      L. Ursino
   7. 39'
      URU
      GOOOAL!J. MasciaPenalty
3. 1. Second half
   2. 46'
      BOL
      Substitution
      ▲F. Saucedo▼A. Jusino
   3. 46'
      BOL
      Substitution
      ▲M. Prost▼E. Triverio
   4. 56'
      BOL
      Yellow card
      R. Amaral
   5. 58'
      BOL
      Yellow card
      A. Jusino
   6. 67'
      BOL
      Yellow card
      Fernando Saucedo
   7. 67'
      URU
      Substitution
      ▲Daniel Bahia▼N. Dibble
   8. 68'
      URU
      Substitution
      ▲D. Mereles▼L. Suhr
   9. 72'
      BOL
      Substitution
      ▲H. Vaca▼R. Amaral
   10. 76'
       URU
       Substitution
       ▲A. Pérez▼Álvaro Fernández
   11. 77'
       URU
       Substitution
       ▲E. Redín▼E. Rodríguez
   12. 82'
       BOL
       Substitution
       ▲Jaime Arrascaita▼L. Ursino
   13. 90'
       URU
       Substitution
       ▲F. Gaimarí▼J. Mascia
   14. 90+3'
       BOL
       Substitution
       ▲L. Demiquel▼D. Wayar