The Strongest beat Universidad Catolica 2-1. The winner had to work for it: 2 from 12 shots. Best on the pitch was F. Martinez, rated 7.5.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2022
   BOL 4-3-3·4-1-4-1 ECU
   Coach: C. Díaz · M. RondelliReferee: Wilton Pereira Sampaio📍 Estadio Hernando Siles
2. 1. First half
   2. 2'
      BOL
      GOOOAL!E. Triverio
   3. 7'
      ECU
      GOOOAL!Ismael Díaz
3. 1. Second half
   2. 49'
      BOL
      Yellow card
      Juan Aponte
   3. 62'
      ECU
      Substitution
      ▲W. Cevallos▼Kevin Minda
   4. 66'
      ECU
      Yellow card
      F. Martinez
   5. 67'
      BOL
      Substitution
      ▲J. Reinoso▼Jaime Arrascaita
   6. 74'
      ECU
      Substitution
      ▲L. Alzugaray▼W. Chalá
   7. 75'
      ECU
      Substitution
      ▲D. Clavijo▼S. Zamora
   8. 76'
      BOL
      Substitution
      ▲Silvio Rojas▼L. Ursino
   9. 78'
      ECU
      Yellow card
      Ismael Díaz
   10. 84'
       BOL
       GOOOAL!R. Amaral
   11. 85'
       BOL
       Yellow card
       R. Amaral
   12. 87'
       BOL
       Substitution
       ▲L. Demiquel▼R. Amaral
   13. 87'
       ECU
       Substitution
       ▲R. Rivas▼L. Loor