Colón beat Penarol 2-1. The winner had to work for it: 2 from 26 shots. Best on the pitch was Luis Rodríguez, rated 7.9.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2022
   ARG 3-1-4-2·4-1-4-1 URU
   Coach: J. Falcioni · M. LarrieraReferee: Wilton Pereira Sampaio📍 Estadio Brigadier General Estanislao López
2. 1. First half
   2. 31'
      ARG
      GOOOAL!Luis Rodríguez
3. 1. Second half
   2. 51'
      ARG
      Yellow card
      R. Delgado
   3. 60'
      URU
      Substitution
      ▲R. Bentancourt▼Agustín Álvarez Martínez
   4. 69'
      ARG
      Substitution
      ▲Facundo Farías▼Luis Rodríguez
   5. 69'
      URU
      Substitution
      ▲B. Mansilla▼Federico Carrizo
   6. 69'
      URU
      GOOOAL!Pablo CeppeliniAssist: B. Mansilla
   7. 77'
      ARG
      Substitution
      ▲R. Abila▼L. Beltrán
   8. 80'
      URU
      Yellow card
      Ramón Arias
   9. 87'
      URU
      Substitution
      ▲H. Menosse▼Pablo Ceppelini
   10. 87'
       URU
       Substitution
       ▲F. Bonifazi▼I. Laquintana
   11. 88'
       URU
       Substitution
       ▲A. Da Silveira▼Ezequiel Busquets
   12. 90'
       ARG
       GOOOAL!Facundo Farías
   13. 90+2'
       ARG
       Yellow card
       Christian Bernardi
   14. 90+2'
       ARG
       Substitution
       ▲C. Vega▼Christian Bernardi