Deportivo Cali beat Boca Juniors 2-0. The winner had to work for it: 2 from 17 shots. Best on the pitch was K. Velasco, rated 8.5.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2022
   COL 4-4-1-1·4-3-1-2 ARG
   Coach: R. Dudamel · S. BattagliaReferee: J. Valenzuela📍 Estadio Deportivo Cali
2. 1. First half
   2. 28'
      COL
      Yellow card
      Jorge Marsiglia
   3. 37'
      COL
      Yellow card
      Guillermo Burdisso
   4. 43'
      ARG
      Substitution
      ▲J. Figal▼Carlos Zambrano
   5. 45+1'
      ARG
      Yellow card
      Darío Benedetto
3. 1. Second half
   2. 58'
      COL
      Substitution
      ▲J. Vásquez▼Y. González
   3. 59'
      ARG
      Substitution
      ▲A. Varela▼J. Ramirez
   4. 68'
      COL
      Substitution
      ▲A. Vuletich▼A. Rodríguez
   5. 69'
      ARG
      Yellow card
      C. Medina
   6. 70'
      COL
      GOOOAL!Guillermo BurdissoAssist: K. Velasco
   7. 77'
      COL
      Substitution
      ▲Carlos Robles▼E. Camargo
   8. 77'
      COL
      Substitution
      ▲J. Caldera▼Christian Mafla
   9. 80'
      COL
      GOOOAL!J. VásquezAssist: K. Velasco
   10. 85'
       ARG
       Substitution
       ▲N. Orsini▼E. Zeballos
   11. 85'
       ARG
       Substitution
       ▲Silvio Romero▼C. Medina
   12. 90'
       ARG
       Yellow card
       J. Campuzano