Boca Juniors beat Always Ready 2-0. The winner had to work for it: 2 from 21 shots. Always Ready played with ten from minute 45. Darío Benedetto scored 2 goals. Best on the pitch was Óscar Romero, rated 9.0.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2022
   ARG 4-1-3-2·4-4-2 BOL
   Coach: S. Battaglia · E. VillegasReferee: G. Tejera📍 Estadio Alberto José Armando
2. 1. First half
   2. 25'
      ARG
      GOOOAL!Darío BenedettoAssist: E. Zeballos
   3. 45'
      ARG
      Yellow card
      G. Avila
   4. 45'
      BOL
      Red card
      Rodrigo Ramallo
   5. 45+1'
      ARG
      Yellow card
      Darío Benedetto
   6. 45+2'
      BOL
      Yellow card
      Juan Arce
3. 1. Second half
   2. 46'
      ARG
      Substitution
      ▲L. Brey▼A. Rossi
   3. 53'
      BOL
      Yellow card
      Nelson Cabrera
   4. 70'
      ARG
      Substitution
      ▲L. Vázquez▼E. Zeballos
   5. 80'
      BOL
      Substitution
      ▲M. Cortés▼G. Cristaldo
   6. 85'
      BOL
      Substitution
      ▲G. Torres▼M. D. Riquelme
   7. 86'
      ARG
      Substitution
      ▲C. Medina▼J. Ramirez
   8. 86'
      BOL
      Substitution
      ▲J. Borja▼Juan Arce
   9. 90'
      BOL
      Substitution
      ▲E. Blanco▼Alejandro Chumacero
   10. 90+6'
       ARG
       GOOOAL!Darío BenedettoAssist: Ó. Romero