Libertad Asuncion beat Caracas FC 2-1. The winner had to work for it: 2 from 21 shots. Best on the pitch was A. Baroja, rated 8.6.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2022
   PAR 4-2-3-1·4-2-3-1 VEN
   Coach: D. Garnero · F. StifanoReferee: F. Tello📍 Estadio Defensores del Chaco
2. 1. First half
   2. 3'
      PAR
      GOOOAL!Óscar Cardozo
   3. 20'
      VEN
      GOOOAL!K. OseiAssist: E. Fereira
   4. 29'
      VEN
      Yellow card
      Rubert Quijada
   5. 30'
      PAR
      Yellow card
      B. Merlini
   6. 34'
      PAR
      GOOOAL!L. MelgarejoAssist: M. Samudio
   7. 41'
      VEN
      Yellow card
      K. Osei
   8. 45+3'
      VEN
      Yellow card
      Eduardo Fereira
3. 1. Second half
   2. 60'
      VEN
      Substitution
      ▲L. González▼L. Ramírez
   3. 60'
      VEN
      Substitution
      ▲A. Zambrano▼S. Guarirapa
   4. 62'
      PAR
      Substitution
      ▲Julio César Enciso▼A. Bareiro
   5. 62'
      PAR
      Substitution
      ▲Héctor Villalba▼B. Merlini
   6. 73'
      VEN
      Substitution
      ▲V. Rodríguez▼C. Suárez
   7. 74'
      VEN
      Yellow card
      Edson Castillo
   8. 82'
      PAR
      Substitution
      ▲H. Caballero▼Óscar Cardozo
   9. 87'
      VEN
      Substitution
      ▲M. Sulbarán▼K. Osei