Colo Colo beat Alianza Lima 2-1. The winner had to work for it: 2 from 14 shots. Best on the pitch was E. Pavez, rated 8.0.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2022
   CHI 4-2-3-1·5-3-2 PER
   Coach: G. Quinteros · C. BustosReferee: E. Ostojich📍 Estadio Monumental David Arellano
2. 1. First half
   2. 27'
      CHI
      GOOOAL!J. LuceroAssist: G. Costa
3. 1. Second half
   2. 46'
      PER
      Substitution
      ▲Edgar Benitez▼O. Valenzuela
   3. 52'
      CHI
      Yellow card
      Óscar Opazo
   4. 56'
      CHI
      GOOOAL!E. PavezAssist: G. Suazo
   5. 64'
      PER
      Substitution
      ▲P. Lavandeira▼Cristian Benavente
   6. 64'
      PER
      Substitution
      ▲R. Rojas▼O. Mora
   7. 64'
      PER
      Substitution
      ▲Arley Rodríguez▼R. Lagos
   8. 69'
      PER
      GOOOAL!Edgar BenitezAssist: P. Lavandeira
   9. 71'
      CHI
      Yellow card
      M. Zaldivia
   10. 75'
       PER
       Yellow card
       Arley Rodríguez
   11. 76'
       CHI
       Substitution
       ▲C. Villanueva▼L. Gil
   12. 77'
       PER
       Substitution
       ▲W. Aguirre▼J. Concha
   13. 82'
       CHI
       Substitution
       ▲Christian Santos▼J. Lucero
   14. 82'
       PER
       Yellow card
       R. Rojas
   15. 85'
       CHI
       Yellow card
       C. Villanueva
   16. 90+2'
       CHI
       Substitution
       ▲Vicente Pizarro▼G. Costa
   17. 90+3'
       PER
       Yellow card
       Pablo Miguez