Club Nacional and Estudiantes de La Plata drew 0-0. Club Nacional controlled the ball — 61% possession — but had nothing to show for it. Best on the pitch was M. Andújar, rated 8.2.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2022
   URU 4-2-3-1·5-3-2 ARG
   Coach: P. Repetto · R. ZielinskiReferee: W. Roldán📍 Estadio Gran Parque Central
2. 1. First half
   2. 29'
      ARG
      Yellow card
      J. Morel
   3. 39'
      URU
      Yellow card
      C. Cándido
3. 1. Second half
   2. 46'
      ARG
      Substitution
      ▲Maximiliano Pellegrino▼J. Morel
   3. 47'
      URU
      Yellow card
      Léo Coelho
   4. 53'
      URU
      Yellow card
      Alex Castro
   5. 57'
      URU
      Substitution
      ▲D. Zabala▼M. Monzeglio
   6. 59'
      ARG
      Yellow card
      Leandro Díaz
   7. 63'
      ARG
      Substitution
      ▲M. Castro▼M. Boselli
   8. 73'
      URU
      Substitution
      ▲B. Ocampo▼A. Trezza
   9. 74'
      URU
      Substitution
      ▲Diego Manuel Rodríguez▼Y. Rodríguez
   10. 74'
       ARG
       Substitution
       ▲F. Zapiola▼G. Del Prete
   11. 80'
       URU
       Substitution
       ▲F. Fagúndez▼F. Carballo
   12. 80'
       URU
       Substitution
       ▲C. Almeida▼C. Cándido
   13. 90+3'
       ARG
       Substitution
       ▲B. Kociubinski▼Fernando Zuqui