Cerro Porteno beat Penarol 1-0. Best on the pitch was Pablo Ceppelini, rated 7.9.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2022
   PAR 4-4-2·4-1-4-1 URU
   Coach: F. Arce · M. LarrieraReferee: W. Roldán📍 Estadio General Pablo Rojas
2. 1. First half
   2. 45+1'
      PAR
      GOOOAL!Á. Cardozo LucenaAssist: C. Aquino
3. 1. Second half
   2. 49'
      PAR
      Substitution
      ▲F. Romero▼Sergio Díaz
   3. 53'
      URU
      Yellow card
      Damian Musto
   4. 53'
      PAR
      Yellow card
      J. Patiño
   5. 54'
      URU
      Substitution
      ▲Walter Gargano▼R. A. Saravia Salvia
   6. 54'
      URU
      Substitution
      ▲L. Viatri▼Federico Carrizo
   7. 64'
      URU
      Yellow card
      E. Elizalde
   8. 65'
      URU
      Substitution
      ▲F. Bonifazi▼E. Elizalde
   9. 71'
      URU
      Yellow card
      L. Viatri
   10. 77'
       PAR
       Substitution
       ▲L. Rivas▼Marcelo Martins Moreno
   11. 77'
       URU
       Substitution
       ▲M. Alonso▼Agustín Álvarez Martínez
   12. 77'
       URU
       Substitution
       ▲R. Bentancourt▼Damian Musto
   13. 79'
       PAR
       Yellow card
       A. Espinola
   14. 83'
       PAR
       Substitution
       ▲Clemente Rolón▼A. Benítez
   15. 87'
       PAR
       Yellow card
       R. Carrascal
   16. 90+3'
       PAR
       Yellow card
       A. Duarte