Always Ready and Deportivo Cali drew 2-2. Best on the pitch was Juan Arce, rated 8.2.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2022
   BOL 4-1-4-1·4-1-4-1 COL
   Coach: E. Villegas · R. DudamelReferee: A. Aragón📍 Estadio Hernando Siles
2. 1. First half
   2. 19'
      BOL
      Yellow card
      J. Adrián
   3. 28'
      BOL
      Yellow card
      Marc Enoumba
   4. 30'
      COL
      Yellow card
      Christian Mafla
   5. 34'
      COL
      Yellow card
      Guillermo Burdisso
   6. 35'
      BOL
      GOOOAL!M. D. RiquelmePenalty
   7. 40'
      BOL
      Yellow card
      Nelson Cabrera
   8. 42'
      BOL
      GOOOAL!Juan ArceAssist: A. Chumacero
   9. 45+3'
      BOL
      Yellow card
      G. Cristaldo
   10. 45+5'
       COL
       GOOOAL!K. VelascoPenalty
3. 1. Second half
   2. 51'
      COL
      Substitution
      ▲Teófilo Gutiérrez▼Y. Congo
   3. 51'
      COL
      Substitution
      ▲O. Segura▼J. Vásquez
   4. 54'
      COL
      GOOOAL!Guillermo BurdissoAssist: K. Velasco
   5. 55'
      COL
      Yellow card
      Teófilo Gutiérrez
   6. 56'
      BOL
      Yellow card
      M. D. Riquelme
   7. 56'
      COL
      Yellow card
      Carlos Robles
   8. 65'
      BOL
      Substitution
      ▲G. Torres▼G. Cristaldo
   9. 77'
      BOL
      Substitution
      ▲E. Blanco▼J. Borja
   10. 78'
       COL
       Yellow card
       A. Rodríguez
   11. 80'
       COL
       Substitution
       ▲H. Mosquera▼A. Rodríguez
   12. 82'
       BOL
       Yellow card
       E. Blanco
   13. 90+2'
       COL
       Substitution
       ▲A. Balanta▼K. Velasco