Estudiantes de La Plata beat Club Nacional 1-0. The winner had to work for it: 1 from 14 shots. Best on the pitch was M. Castro, rated 7.6.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2022
   ARG 4-3-1-2·4-2-3-1 URU
   Coach: R. Zielinski · P. RepettoReferee: W. Roldán📍 Estadio Jorge Luis Hirschi
2. 1. First half
   2. 17'
      URU
      Yellow card
      L. Lozano
   3. 34'
      URU
      Yellow card
      J. Rodriguez
   4. 41'
      ARG
      GOOOAL!M. CastroAssist: L. Díaz
   5. 42'
      URU
      Substitution
      ▲D. Zabala▼B. Ocampo
3. 1. Second half
   2. 59'
      URU
      Substitution
      ▲L. Otormín▼M. Monzeglio
   3. 63'
      ARG
      Yellow card
      F. Noguera
   4. 63'
      ARG
      Substitution
      ▲J. Morel▼Leandro Díaz
   5. 66'
      ARG
      Yellow card
      J. Morel
   6. 68'
      URU
      Yellow card
      A. Trezza
   7. 71'
      ARG
      Substitution
      ▲Maximiliano Pellegrino▼M. Castro
   8. 75'
      URU
      Yellow card
      Y. Rodríguez
   9. 81'
      ARG
      Substitution
      ▲F. Zapiola▼G. Del Prete
   10. 84'
       URU
       Substitution
       ▲I. Ramírez▼A. Trezza
   11. 84'
       URU
       Substitution
       ▲C. Almeida▼J. Rodriguez
   12. 90'
       URU
       Yellow card
       Léo Coelho