Colón beat Cerro Porteno 2-1. Cerro Porteno controlled the ball — 59% possession — but had nothing to show for it. The winner had to work for it: 2 from 15 shots. Cerro Porteno played with ten from minute 90. Best on the pitch was Facundo Farías, rated 8.5.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2022
   ARG 4-4-2·5-4-1 PAR
   Coach: J. Falcioni · F. ArceReferee: Raphael Claus📍 Estadio Brigadier General Estanislao López
2. 1. First half
   2. 21'
      ARG
      GOOOAL!Facundo FaríasAssist: C. Bernardi
   3. 42'
      PAR
      Yellow card
      J. Patiño
3. 1. Second half
   2. 46'
      PAR
      Substitution
      ▲A. Galeano▼W. Riveros
   3. 60'
      PAR
      Substitution
      ▲L. Rivas▼A. Rodríguez
   4. 60'
      PAR
      Substitution
      ▲A. Oviedo▼F. Romero
   5. 61'
      PAR
      Substitution
      ▲D. Bobadilla▼R. Piris Da Motta
   6. 64'
      ARG
      Yellow card
      R. Delgado
   7. 69'
      ARG
      GOOOAL!C. Bernardi
   8. 72'
      PAR
      Substitution
      ▲F. Franco▼A. Espinola
   9. 73'
      PAR
      GOOOAL!Marcelo Martins MorenoAssist: L. Rivas
   10. 77'
       PAR
       Yellow card
       D. Bobadilla
   11. 80'
       ARG
       Substitution
       ▲R. Abila▼L. Beltrán
   12. 85'
       ARG
       Substitution
       ▲N. Gallardo▼A. Teuten
   13. 86'
       ARG
       Substitution
       ▲S. Pierotti▼Facundo Farías
   14. 87'
       ARG
       Yellow card
       S. Pierotti
   15. 90+4'
       PAR
       Red card
       F. Franco