Olimpia beat Penarol 1-0. The winner had to work for it: 1 from 12 shots. Best on the pitch was Pablo Ceppelini, rated 8.3.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2022
   PAR 3-4-3·4-2-3-1 URU
   Coach: J. Cáceres · M. LarrieraReferee: Anderson Daronco📍 Estadio Defensores del Chaco
2. 1. First half
   2. 5'
      PAR
      Yellow card
      L. Zárate
   3. 19'
      PAR
      Substitution
      ▲F. Cardozo▼J. Recalde
   4. 21'
      URU
      Yellow card
      Damian Musto
   5. 33'
      PAR
      GOOOAL!S. SalcedoAssist: F. Cardozo
   6. 36'
      PAR
      Yellow card
      M. Gómez
3. 1. Second half
   2. 46'
      URU
      Substitution
      ▲M. Alonso▼Federico Carrizo
   3. 53'
      URU
      Yellow card
      E. Elizalde
   4. 54'
      URU
      Substitution
      ▲R. A. Saravia Salvia▼Walter Gargano
   5. 65'
      PAR
      Substitution
      ▲Hugo Quintana▼Richard Ortiz
   6. 69'
      URU
      Substitution
      ▲Agustín Álvarez Martínez▼Damian Musto
   7. 69'
      URU
      Substitution
      ▲M. Aguirregaray▼E. Elizalde
   8. 78'
      PAR
      Substitution
      ▲W. González▼Guillermo Paiva
   9. 79'
      PAR
      Substitution
      ▲V. Salazar▼I. Torres
   10. 84'
       URU
       Substitution
       ▲L. Viatri▼I. Laquintana
   11. 88'
       PAR
       Yellow card
       F. Cardozo