Boca Juniors beat Always Ready 0-1. The winner had to work for it: 1 from 14 shots. Always Ready played with ten from minute 86. Best on the pitch was A. Rossi, rated 8.0.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2022
   BOL 4-4-2·4-1-4-1 ARG
   Coach: E. Villegas · S. BattagliaReferee: K. Ortega📍 Estadio Hernando Siles
2. 1. First half
   2. 34'
      BOL
      Yellow card
      Juan Arce
   3. 37'
      ARG
      GOOOAL!Silvio RomeroPenalty
   4. 41'
      ARG
      Yellow card
      Óscar Romero
   5. 45+4'
      ARG
      Yellow card
      L. Brey
3. 1. Second half
   2. 46'
      BOL
      Substitution
      ▲M. D. Riquelme▼J. Borja
   3. 46'
      BOL
      Substitution
      ▲Alejandro Chumacero▼J. Adrián
   4. 59'
      ARG
      Substitution
      ▲N. Orsini▼L. Vázquez
   5. 59'
      ARG
      Substitution
      ▲C. Medina▼J. Ramirez
   6. 63'
      ARG
      Yellow card
      Frank Fabra
   7. 64'
      ARG
      Yellow card
      A. Rossi
   8. 74'
      ARG
      Substitution
      ▲J. Campuzano▼Óscar Romero
   9. 81'
      BOL
      Substitution
      ▲M. Cortés▼E. Blanco
   10. 85'
       ARG
       Substitution
       ▲E. Zeballos▼Silvio Romero
   11. 86'
       BOL
       Red card
       M. Cortés
   12. 90+4'
       BOL
       Yellow card
       Alejandro Chumacero