Colón beat Olimpia 2-1. The winner had to work for it: 2 from 20 shots. F. Lértora scored 2 goals. Best on the pitch was F. Lértora, rated 9.0.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2022
   ARG 3-4-2-1·4-4-2 PAR
   Coach: J. Falcioni · J. CáceresReferee: W. Roldán📍 Estadio Brigadier General Estanislao López
2. 1. First half
   2. 7'
      PAR
      GOOOAL!Hugo QuintanaAssist: D. González
   3. 29'
      PAR
      Yellow card
      I. Torres
   4. 41'
      ARG
      GOOOAL!F. LértoraAssist: C. Bernardi
   5. 45+2'
      ARG
      Yellow card
      R. Aliendro
   6. 45+2'
      PAR
      Yellow card
      Guillermo Paiva
3. 1. Second half
   2. 64'
      PAR
      Yellow card
      W. Candia
   3. 69'
      PAR
      Yellow card
      S. Salcedo
   4. 72'
      PAR
      Substitution
      ▲A. Silva▼Hugo Quintana
   5. 76'
      ARG
      Substitution
      ▲R. Abila▼L. Beltrán
   6. 78'
      PAR
      Substitution
      ▲W. González▼Guillermo Paiva
   7. 78'
      PAR
      Substitution
      ▲A. Zárate▼W. Candia
   8. 84'
      ARG
      GOOOAL!F. Lértora
   9. 85'
      PAR
      Substitution
      ▲Nestor Camacho▼I. Torres
   10. 90+3'
       PAR
       Yellow card
       V. Salazar
   11. 90+3'
       ARG
       Yellow card
       F. Lértora