Deportivo Cali beat Always Ready 3-0. Always Ready played with ten from minute 70. J. Vásquez scored 2 goals. Best on the pitch was J. Vásquez, rated 9.6.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2022
   COL 4-2-3-1·4-1-4-1 BOL
   Coach: R. Dudamel · E. VillegasReferee: A. Herrera📍 Estadio Deportivo Cali
2. 1. First half
   2. 12'
      COL
      GOOOAL!J. VásquezAssist: Y. González
   3. 15'
      BOL
      Yellow card
      G. Torres
   4. 31'
      BOL
      Yellow card
      Nelson Cabrera
   5. 40'
      BOL
      Yellow card
      Marc Enoumba
3. 1. Second half
   2. 46'
      BOL
      Substitution
      ▲Juan Arce▼C. Arabe
   3. 55'
      COL
      GOOOAL!J. Vásquez
   4. 66'
      COL
      Yellow card
      Y. González
   5. 69'
      BOL
      Substitution
      ▲M. D. Riquelme▼G. Torres
   6. 70'
      BOL
      Yellow card
      Marc Enoumba
   7. 70'
      BOL
      Red card
      Marc Enoumba
   8. 74'
      COL
      GOOOAL!H. MosqueraAssist: J. Vásquez
   9. 77'
      BOL
      Substitution
      ▲D. Medina▼J. Adrián
   10. 78'
       COL
       Substitution
       ▲J. Mina▼A. Gutiérrez
   11. 78'
       COL
       Substitution
       ▲C. Lucumi▼Y. González
   12. 83'
       BOL
       Substitution
       ▲J. Mamani▼Alejandro Chumacero
   13. 84'
       BOL
       Substitution
       ▲J. Borja▼G. Cristaldo
   14. 85'
       BOL
       Yellow card
       E. Blanco
   15. 86'
       COL
       Substitution
       ▲O. Segura▼H. Mosquera
   16. 86'
       COL
       Substitution
       ▲D. Luna▼Teófilo Gutiérrez
   17. 89'
       COL
       Substitution
       ▲J. Ramos▼J. Vásquez