Penarol beat Colón 2-1. The winner had to work for it: 2 from 15 shots. Best on the pitch was Pablo Ceppelini, rated 8.9.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2022
   URU 4-4-2·3-4-2-1 ARG
   Coach: M. Larriera · J. FalcioniReferee: Anderson Daronco📍 Estadio Campeón del Siglo
2. 1. First half
   2. 32'
      ARG
      GOOOAL!Facundo Farías
   3. 38'
      ARG
      Yellow card
      P. Goltz
3. 1. Second half
   2. 46'
      URU
      Substitution
      ▲I. Laquintana▼Walter Gargano
   3. 48'
      URU
      GOOOAL!Pablo Ceppelini
   4. 55'
      URU
      Substitution
      ▲Agustín Álvarez Martínez▼R. Bentancourt
   5. 58'
      ARG
      Yellow card
      R. Delgado
   6. 90+4'
      ARG
      Yellow card
      A. Teuten
   7. 90+7'
      URU
      GOOOAL!H. MenosseAssist: R. Arias
   8. 90+9'
      ARG
      Substitution
      ▲G. Nardelli▼R. Aliendro
   9. 90+9'
      ARG
      Substitution
      ▲T. Moschión▼F. Garcés
   10. 90+10'
       ARG
       Substitution
       ▲S. Pierotti▼F. Lértora
   11. 90+13'
       URU
       Substitution
       ▲A. Da Silveira▼M. Alonso
   12. 90+13'
       URU
       Substitution
       ▲A. Cruz▼H. Menosse
   13. 90+13'
       ARG
       Substitution
       ▲R. Abila▼Christian Bernardi
   14. 90+23'
       ARG
       Substitution
       ▲Mauro Formica▼P. Goltz
   15. 90+23'
       URU
       Substitution
       ▲Damian Musto▼L. Viatri