Libertad Asuncion beat The Strongest 4-1. The Strongest played with ten from minute 66. William Mendieta scored 2 goals. Best on the pitch was William Mendieta, rated 9.7.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2022
   PAR 4-1-4-1·4-1-4-1 BOL
   Coach: D. Garnero · C. DíazReferee: F. Tello📍 Estadio Defensores del Chaco
2. 1. First half
   2. 25'
      PAR
      GOOOAL!L. MelgarejoAssist: W. Mendieta
   3. 33'
      PAR
      Yellow card
      B. Merlini
   4. 35'
      BOL
      Yellow card
      Juan Aponte
   5. 41'
      BOL
      GOOOAL!L. UrsinoAssist: E. Triverio
3. 1. Second half
   2. 50'
      BOL
      Yellow card
      F. Saucedo
   3. 55'
      BOL
      Yellow card
      Ismael Benegas
   4. 55'
      PAR
      GOOOAL!William MendietaPenalty
   5. 56'
      BOL
      Yellow card
      E. Triverio
   6. 61'
      BOL
      Substitution
      ▲H. Vaca▼F. Saucedo
   7. 66'
      BOL
      Yellow card
      Juan Aponte
   8. 66'
      BOL
      Red card
      Juan Aponte
   9. 69'
      BOL
      Substitution
      ▲Jaime Arrascaita▼B. Cascini
   10. 70'
       PAR
       GOOOAL!Roque Santa Cruz
   11. 71'
       PAR
       Substitution
       ▲Ivan Franco▼Cristian Riveros
   12. 76'
       PAR
       Yellow card
       Alex Terra
   13. 77'
       PAR
       Substitution
       ▲Óscar Cardozo▼Roque Santa Cruz
   14. 77'
       PAR
       Substitution
       ▲A. Bareiro▼B. Merlini
   15. 81'
       PAR
       Yellow card
       H. Caballero
   16. 82'
       BOL
       Substitution
       ▲M. Prost▼E. Triverio
   17. 82'
       BOL
       Substitution
       ▲O. Ribera▼D. Wayar
   18. 82'
       BOL
       Substitution
       ▲R. Amaral▼L. Ursino
   19. 87'
       PAR
       Substitution
       ▲M. Espinoza▼H. Caballero
   20. 87'
       PAR
       Substitution
       ▲Diego Gómez▼Miguel Samudio
   21. 90'
       PAR
       GOOOAL!William MendietaAssist: I. Franco
   22. 90+2'
       PAR
       Yellow card
       Diego Gómez