Boca Juniors beat Deportivo Cali 1-0. The winner had to work for it: 1 from 19 shots. Best on the pitch was Óscar Romero, rated 7.9.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2022
   ARG 4-1-4-1·4-2-3-1 COL
   Coach: S. Battaglia · R. DudamelReferee: P. Maza📍 Estadio Alberto José Armando
2. 1. First half
   2. 20'
      ARG
      Yellow card
      Frank Fabra
   3. 38'
      COL
      Yellow card
      Y. Congo
   4. 45'
      COL
      Yellow card
      E. Camargo
   5. 45+3'
      COL
      Yellow card
      J. Vásquez
   6. 45+4'
      COL
      Yellow card
      Teófilo Gutiérrez
3. 1. Second half
   2. 53'
      COL
      Substitution
      ▲Carlos Robles▼Christian Mafla
   3. 54'
      ARG
      GOOOAL!A. Varela
   4. 56'
      ARG
      Yellow card
      J. Figal
   5. 60'
      COL
      Substitution
      ▲H. Mosquera▼Y. González
   6. 62'
      ARG
      Substitution
      ▲J. Ramirez▼Silvio Romero
   7. 68'
      ARG
      Substitution
      ▲L. Vázquez▼Darío Benedetto
   8. 76'
      COL
      Substitution
      ▲C. Lucumi▼Y. Congo
   9. 77'
      ARG
      Substitution
      ▲C. Medina▼E. Zeballos
   10. 89'
       ARG
       Yellow card
       C. Medina