Club Nacional beat Independiente Medellin 2-1. Independiente Medellin controlled the ball — 63% possession — but had nothing to show for it. The winner had to work for it: 2 from 18 shots. Best on the pitch was F. Noguera, rated 7.7.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2023
   URU 4-3-3·4-4-2 COL
   Coach: Á. Gutiérrez · D. GonzálezReferee: Dario Herrera, Argentina📍 Estadio Gran Parque Central
2. 1. First half
   2. 1'
      URU
      Yellow card
      F. Noguera
   3. 37'
      URU
      GOOOAL!G. Pereiro
   4. 38'
      URU
      Yellow card
      G. Pereiro
   5. 45+2'
      COL
      Yellow card
      Victor Moreno
3. 1. Second half
   2. 58'
      URU
      Substitution
      ▲B. Damiani▼I. Ramírez
   3. 59'
      URU
      Yellow card
      Y. Rodríguez
   4. 63'
      COL
      Yellow card
      D. Cambindo
   5. 63'
      COL
      Substitution
      ▲D. Quiñónes▼Felipe Pardo
   6. 63'
      COL
      Substitution
      ▲E. Batalla▼M. Monsalve
   7. 67'
      URU
      Substitution
      ▲M. Monzeglio▼Y. Rodríguez
   8. 67'
      URU
      Substitution
      ▲M. Montiel▼G. Pereiro
   9. 69'
      COL
      Yellow card
      Daniel Torres
   10. 73'
       URU
       Substitution
       ▲Diego Manuel Rodríguez▼F. Ginella
   11. 79'
       COL
       GOOOAL!L. PonsAssist: D. Quiñónes
   12. 80'
       URU
       Yellow card
       M. Montiel
   13. 81'
       COL
       Substitution
       ▲Andres Ricaurte▼Daniel Torres
   14. 82'
       URU
       Yellow card
       C. Cándido
   15. 90'
       COL
       Yellow card
       Andres Cadavid
   16. 90+1'
       COL
       Yellow card
       L. Pons
   17. 90+6'
       URU
       GOOOAL!F. NogueraAssist: B. Damiani
   18. 90+11'
       COL
       Yellow card
       Andres Ricaurte
   19. 90+12'
       COL
       Yellow card
       D. Quiñónes