Independiente Medellin beat Club Nacional 2-1. The winner had to work for it: 2 from 17 shots. Best on the pitch was D. Quiñónes, rated 7.7.

1. 0'
   ⚽Kick-off
   CONMEBOL Libertadores 2023
   COL 4-2-3-1·4-2-3-1 URU
   Coach: S. Botero · Á. GutiérrezReferee: D. Haro📍 Estadio Atanasio Girardot
2. 1. First half
   2. 6'
      COL
      Yellow card
      Jonathan Marulanda
   3. 12'
      URU
      GOOOAL!Diego Manuel RodríguezAssist: F. Fagúndez
   4. 24'
      URU
      Yellow card
      C. Cándido
   5. 25'
      COL
      GOOOAL!A. IbargüenAssist: E. Cetré
   6. 38'
      COL
      Yellow card
      Daniel Torres
3. 1. Second half
   2. 65'
      COL
      Substitution
      ▲D. Quiñónes▼E. Cetre
   3. 66'
      URU
      Substitution
      ▲G. Pereiro▼F. Fagúndez
   4. 68'
      COL
      GOOOAL!D. QuiñónesAssist: J. Alvarado
   5. 74'
      COL
      Substitution
      ▲D. Loaiza▼L. Pons
   6. 74'
      URU
      Substitution
      ▲C. Almeida▼C. Cándido
   7. 74'
      URU
      Substitution
      ▲Emmanuel Gigliotti▼I. Ramírez
   8. 74'
      URU
      Substitution
      ▲F. Martínez▼A. Trezza
   9. 80'
      URU
      Yellow card
      D. Zabala
   10. 86'
       URU
       Substitution
       ▲M. Montiel▼Diego Manuel Rodríguez
   11. 87'
       COL
       Substitution
       ▲J. Monroy▼Jonathan Marulanda
   12. 88'
       COL
       Substitution
       ▲Jhon Palacios▼A. Ibargüen
   13. 90'
       URU
       Yellow card
       G. Pereiro