Deportivo Cali beat Club Guarani 1-0. The winner had to work for it: 1 from 21 shots. Club Guarani played with ten from minute 56. Best on the pitch was John Mosquera, rated 8.1.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2019
   COL 4-4-2·4-2-3-1 PAR
   Coach: L. Pusineri · G. FlorentínReferee: Diego Haro, Peru📍 Estadio Deportivo Cali
2. 1. First half
   2. 22'
      COL
      Yellow card
      K. Velasco
   3. 44'
      COL
      GOOOAL!K. Velasco
   4. 45'
      PAR
      Yellow card
      J. Morel
3. 1. Second half
   2. 47'
      PAR
      Yellow card
      Rodrigo Fernandez
   3. 56'
      PAR
      Red card
      Rodrigo Fernandez
   4. 63'
      COL
      Substitution
      ▲Andres Colorado▼Juan Caicedo
   5. 67'
      COL
      Substitution
      ▲Carlos Carbonero▼K. Velasco
   6. 71'
      COL
      Yellow card
      Christian Rivera
   7. 74'
      PAR
      Substitution
      ▲Rodolfo Gamarra▼C. Aquino
   8. 76'
      PAR
      Substitution
      ▲Rodney Redes▼O. Gaona Lugo
   9. 77'
      COL
      Yellow card
      Carlos Carbonero
   10. 82'
       COL
       Substitution
       ▲César Amaya▼D. Delgado
   11. 83'
       COL
       Yellow card
       Darwin Andrade
   12. 83'
       PAR
       Yellow card
       Luis De la Cruz
   13. 87'
       PAR
       Substitution
       ▲Wilson Leiva▼José Ortigoza
   14. 89'
       PAR
       Yellow card
       Victor Centurion
   15. 90'
       PAR
       Yellow card
       Luis De la Cruz
   16. 90'
       PAR
       Red card
       C. Aquino
   17. 90'
       PAR
       Red card
       Luis De la Cruz