Penarol beat Deportivo Cali 2-0. The winner had to work for it: 2 from 12 shots. Best on the pitch was L. Viatri, rated 8.3.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2019
   URU 4-4-2·4-2-3-1 COL
   Coach: D. López · L. PusineriReferee: Nestor Pitana, Argentina📍 Campeón del Siglo
2. 1. First half
   2. 16'
      COL
      Yellow card
      Francisco Delorenzi
   3. 30'
      URU
      Yellow card
      Ignacio Lores
3. 1. Second half
   2. 50'
      URU
      GOOOAL!A. CanobbioAssist: Lucas Viatri
   3. 52'
      COL
      Yellow card
      John Mosquera
   4. 60'
      URU
      Substitution
      ▲Rodrigo Rojo▼Ignacio Lores
   5. 66'
      COL
      Substitution
      ▲Feiver Mercado▼John Mosquera
   6. 72'
      URU
      Yellow card
      Walter Gargano
   7. 73'
      URU
      GOOOAL!Walter GarganoAssist: Lucas Viatri
   8. 79'
      COL
      Yellow card
      Matías Cabrera
   9. 81'
      URU
      Yellow card
      Rodrigo Rojo
   10. 82'
       COL
       Substitution
       ▲K. Velasco▼Darwin Andrade
   11. 87'
       URU
       Substitution
       ▲Jesús Trindade▼A. Canobbio
   12. 90'
       URU
       Substitution
       ▲Luis Acevedo▼Gabriel Fernández