Deportes Tolima beat Deportivo Cali 3-0. Deportivo Cali controlled the ball — 67% possession — but had nothing to show for it. Deportivo Cali played with ten from minute 45. Best on the pitch was J. Campaz, rated 7.7.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   COL 3-4-2-1·4-2-3-1 COL
   Coach: H. Torres · A. AriasReferee: M. Herrera📍 Estadio Manuel Murillo Toro
2. 1. First half
   2. 9'
      COL
      GOOOAL!L. Miranda
   3. 12'
      COL
      GOOOAL!Sergio MosqueraPenalty
   4. 20'
      COL
      Yellow card
      Andrey Estupinan
   5. 20'
      COL
      Yellow card
      J. Valencia
   6. 24'
      COL
      Yellow card
      A. Arroyo
   7. 25'
      COL
      Yellow card
      Juan Angulo
   8. 39'
      COL
      Substitution
      ▲William Parra▼C. Sierra
   9. 45'
      COL
      Yellow card
      A. Balanta
   10. 45'
       COL
       Red card
       A. Rodríguez
3. 1. Second half
   2. 46'
      COL
      Substitution
      ▲J. Ramos▼K. Velasco
   3. 46'
      COL
      Substitution
      ▲F. Torres▼A. Arroyo
   4. 52'
      COL
      Yellow card
      William Parra
   5. 52'
      COL
      Substitution
      ▲Gastón Rodríguez▼J. Vásquez
   6. 59'
      COL
      Substitution
      ▲H. Gómez▼Juan Angulo
   7. 67'
      COL
      GOOOAL!J. CampazAssist: J. Ríos
   8. 68'
      COL
      Substitution
      ▲J. Ramírez▼A. Balanta
   9. 69'
      COL
      Yellow card
      Andrey Estupinan
   10. 69'
       COL
       Red card
       Andrey Estupinan
   11. 76'
       COL
       Substitution
       ▲J. Nieto▼J. Campaz
   12. 78'
       COL
       Substitution
       ▲G. Ramírez▼J. Ortiz
   13. 83'
       COL
       Yellow card
       Sergio Mosquera
   14. 90'
       COL
       Yellow card
       Jorge Arias