Guabirá beat Nacional Potosí 4-1. Nacional Potosí played with ten from minute 64. Best on the pitch was Gustavo Peredo, rated 8.3.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   BOL 4-4-2·4-3-3 BOL
   Coach: V. Andrada · A. PeñaReferee: L. Yrusta Campos📍 Estadio Gilberto Parada
2. 1. First half
   2. 18'
      BOL
      Yellow card
      O. Añez
   3. 26'
      BOL
      GOOOAL!S. GulartePenalty
   4. 33'
      BOL
      Yellow card
      Oscar Vaca
   5. 37'
      BOL
      GOOOAL!Luis HurtadoAssist: G. Peredo
   6. 40'
      BOL
      Substitution
      ▲L. Pavia▼L. Justiniano
   7. 43'
      BOL
      Yellow card
      Bruno Pascua
   8. 45'
      BOL
      Yellow card
      Juan Mercado
3. 1. Second half
   2. 58'
      BOL
      Substitution
      ▲R. Cuellar Orti▼P. Jiménez
   3. 58'
      BOL
      Substitution
      ▲Edenilson▼H. Reina
   4. 61'
      BOL
      Substitution
      ▲D. Hoyos▼Bruno Pascua
   5. 64'
      BOL
      Yellow card
      Oscar Vaca
   6. 64'
      BOL
      Red card
      Oscar Vaca
   7. 67'
      BOL
      Substitution
      ▲W. Álvarez▼Luis Hurtado
   8. 74'
      BOL
      GOOOAL!D. HoyosAssist: J. Vogliotti
   9. 76'
      BOL
      GOOOAL!Gustavo PeredoAssist: K. Mina
   10. 77'
       BOL
       Substitution
       ▲J. Rioja▼Miguel Quiroga
   11. 78'
       BOL
       Substitution
       ▲Rodrigo Vargas▼S. Gularte
   12. 87'
       BOL
       Yellow card
       Heber Leanos
   13. 90'
       BOL
       Yellow card
       Alexis Hinestroza
   14. 90'
       BOL
       Yellow card
       L. Torrico
   15. 90'
       BOL
       Yellow card
       Y. Roca
   16. 90+2'
       BOL
       GOOOAL!J. VogliottiAssist: H. Leaños