Cerro Largo and Penarol drew 2-2. Best on the pitch was Agustín Álvarez Martínez, rated 7.7.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   URU 4-5-1·4-3-3 URU
   Coach: L. Núñez · M. LarrieraReferee: D. Riveiro📍 Parque Alfredo Víctor Viera
2. 1. First half
   2. -5'
      URU
      Yellow card
      C. Núñez
   3. 20'
      URU
      Substitution
      ▲G. Machado▼G. Lamardo
   4. 20'
      URU
      GOOOAL!F. FormilianoAssist: G. Kagelmacher
   5. 38'
      URU
      Yellow card
      G. Baez Corradi
   6. 40'
      URU
      Substitution
      ▲R. Abascal▼F. Formiliano
3. 1. Second half
   2. 50'
      URU
      GOOOAL!D. TeransAssist: J. Piquerez
   3. 51'
      URU
      Yellow card
      Maxi Pereira
   4. 56'
      URU
      Yellow card
      R. Abascal
   5. 59'
      URU
      Yellow card
      M. Brasil
   6. 60'
      URU
      Yellow card
      Walter Gargano
   7. 68'
      URU
      Substitution
      ▲Leandro Onetto▼F. Rodríguez
   8. 68'
      URU
      Substitution
      ▲M. Estol▼H. Pereira
   9. 71'
      URU
      Substitution
      ▲Gonzalo Freitas▼Walter Gargano
   10. 71'
       URU
       Substitution
       ▲N. Schiappacasse▼D. Terans
   11. 72'
       URU
       GOOOAL!M. EstolPenalty
   12. 79'
       URU
       Yellow card
       G. Machado
   13. 84'
       URU
       Substitution
       ▲A. Nahuelpán▼F. Torres
   14. 84'
       URU
       Substitution
       ▲Franco Martínez▼Maxi Pereira
   15. 86'
       URU
       Substitution
       ▲F. García▼E. Etcheverry
   16. 86'
       URU
       Substitution
       ▲T. Nascente▼Á. Cayetano
   17. 90'
       URU
       Yellow card
       Gonzalo Freitas
   18. 90+5'
       URU
       GOOOAL!E. Borges