12 de Octubre beat Rosario Central 1-0. Rosario Central controlled the ball — 73% possession — but had nothing to show for it. Best on the pitch was M. Cardozo, rated 8.0.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   PAR 4-4-2·4-2-3-1 ARG
   Coach: P. Sarabia · C. GonzálezReferee: J. Soto📍 Estadio Luís Alfonso Giagni
2. 1. First half
   2. 39'
      ARG
      Yellow card
      Fernando Torrent
3. 1. Second half
   2. 46'
      ARG
      Yellow card
      J. Laso
   3. 58'
      PAR
      Substitution
      ▲David Mendieta Alfonso▼Richard Salinas
   4. 58'
      PAR
      Substitution
      ▲Diego Ríos▼Victor Cáceres
   5. 59'
      PAR
      Substitution
      ▲J. Marabel▼A. Núñez
   6. 61'
      PAR
      Yellow card
      J. Marabel
   7. 67'
      ARG
      Substitution
      ▲F. Lo Celso▼L. Ferreyra
   8. 68'
      ARG
      Substitution
      ▲L. Blanco▼G. Avila
   9. 69'
      PAR
      GOOOAL!P. VelázquezAssist: A. Shuartzman
   10. 76'
       ARG
       Substitution
       ▲A. Marinelli▼D. Zabala
   11. 76'
       ARG
       Substitution
       ▲L. Dupuy▼L. Gamba
   12. 77'
       PAR
       Substitution
       ▲David Mendieta Chávez▼P. Velázquez
   13. 84'
       PAR
       Yellow card
       Diego Ríos
   14. 87'
       PAR
       Substitution
       ▲J. Ojeda▼A. Shuartzman