Independiente beat Guabirá 1-3. Guabirá controlled the ball — 61% possession — but had nothing to show for it. J. Herrera scored 3 goals. Best on the pitch was J. Herrera, rated 9.3.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   BOL 4-4-2·5-3-2 ARG
   Coach: V. Andrada · J. FalcioniReferee: D. Haro📍 Estadio Gilberto Parada
2. 1. First half
   2. 8'
      ARG
      GOOOAL!J. Herrera
   3. 22'
      BOL
      Yellow card
      Juan Mercado
   4. 24'
      ARG
      Yellow card
      J. Herrera
   5. 30'
      ARG
      Yellow card
      Andrés Roa
   6. 35'
      ARG
      GOOOAL!J. Herrera
3. 1. Second half
   2. 46'
      BOL
      Substitution
      ▲D. Hoyos▼F. Domínguez
   3. 52'
      ARG
      GOOOAL!J. Herrera
   4. 58'
      BOL
      Substitution
      ▲Bruno Pascua▼K. Mina
   5. 59'
      BOL
      Substitution
      ▲W. Álvarez▼J. Vogliotti
   6. 67'
      BOL
      Yellow card
      Bruno Pascua
   7. 68'
      ARG
      Substitution
      ▲J. Pacchini▼L. Romero
   8. 68'
      ARG
      Substitution
      ▲B. Martinez▼Andrés Roa
   9. 72'
      ARG
      Substitution
      ▲N. Messiniti▼J. Herrera
   10. 80'
       BOL
       Yellow card
       F. Supayabe
   11. 84'
       BOL
       Substitution
       ▲N. Amarilla▼Heber Leanos
   12. 85'
       BOL
       Substitution
       ▲C. Góngora▼Luis Hurtado
   13. 87'
       ARG
       Substitution
       ▲T. A. Pozzo▼D. Blanco
   14. 87'
       ARG
       Substitution
       ▲G. Asis▼Fabricio Bustos
   15. 89'
       BOL
       GOOOAL!Bruno PascuaAssist: D. Hoyos