Lanús beat Aragua FC 0-1. The winner had to work for it: 1 from 20 shots. Aragua FC played with ten from minute 50. Best on the pitch was A. Pérez, rated 8.0.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   VEN 4-4-2·4-1-4-1 ARG
   Coach: E. García · L. ZubeldíaReferee: R. Orozco📍 Estadio Olímpico de la UCV
2. 1. First half
   2. 45'
      VEN
      Yellow card
      R. Arace
   3. 45'
      ARG
      Yellow card
      A. Bernabei
   4. 45'
      ARG
      Yellow card
      José Sand
3. 1. Second half
   2. 50'
      VEN
      Red card
      A. Stephens
   3. 56'
      ARG
      Substitution
      ▲N. Orsini▼A. Bernabei
   4. 66'
      VEN
      Substitution
      ▲D. Febles▼J. Duche
   5. 67'
      ARG
      Yellow card
      F. Pérez
   6. 68'
      ARG
      Substitution
      ▲F. Orozco▼F. Pérez
   7. 69'
      VEN
      Yellow card
      Héctor Pérez Ramírez
   8. 78'
      ARG
      Substitution
      ▲José Manuel López▼P. De la Vega
   9. 78'
      ARG
      Substitution
      ▲Facundo Quignon▼M. Esquivel
   10. 78'
       ARG
       Substitution
       ▲Brian Aguirre▼J. Gómez
   11. 81'
       VEN
       Substitution
       ▲P. Álvarez▼R. Arace
   12. 81'
       VEN
       Substitution
       ▲O. Zapata▼Héctor Pérez Ramírez
   13. 88'
       ARG
       Yellow card
       Guillermo Burdisso
   14. 90'
       ARG
       GOOOAL!José Manuel LópezAssist: F. Orozco