Libertad Asuncion beat Palestino 2-0. The winner had to work for it: 2 from 19 shots. Palestino played with ten from minute 54. Best on the pitch was Leonel Vangioni, rated 8.3.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   PAR 4-4-2·4-2-3-1 CHI
   Coach: D. Garnero · J. SierraReferee: O. Bracamonte📍 Estadio Dr. Nicolás Leoz
2. 1. First half
   2. 3'
      CHI
      Yellow card
      P. Alvarado
   3. 22'
      CHI
      Yellow card
      Agustin Farias
   4. 33'
      PAR
      Yellow card
      A. Bareiro
   5. 41'
      CHI
      Yellow card
      V. Fernández
3. 1. Second half
   2. 54'
      CHI
      Yellow card
      Agustin Farias
   3. 54'
      CHI
      Red card
      Agustin Farias
   4. 56'
      CHI
      Substitution
      ▲N. Berardo▼V. Fernández
   5. 57'
      CHI
      Substitution
      ▲S. Martínez▼B. Carrasco
   6. 67'
      PAR
      Yellow card
      Leonel Vangioni
   7. 70'
      PAR
      Substitution
      ▲A. Oviedo▼I. Ramirez
   8. 71'
      PAR
      Substitution
      ▲R. Bogarin▼S. Ferreira
   9. 71'
      PAR
      GOOOAL!R. BogarinAssist: L. Vangioni
   10. 73'
       PAR
       GOOOAL!A. OviedoAssist: L. Vangioni
   11. 78'
       PAR
       Substitution
       ▲I. Piris▼P. Delvalle
   12. 78'
       PAR
       Substitution
       ▲Héctor Villalba▼A. Bareiro
   13. 81'
       CHI
       Substitution
       ▲B. Barticciotto▼M. Dávila
   14. 87'
       PAR
       Substitution
       ▲Lucas Sanabria▼H. Martínez