Penarol beat Sport Huancayo 5-1. Agustín Álvarez Martínez scored 2 goals. Best on the pitch was Jesús Trindade, rated 8.9.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   URU 4-4-2·4-2-3-1 PER
   Coach: M. Larriera · W. ValenciaReferee: Á. Cajas📍 Estadio Campeón del Siglo
2. 1. First half
   2. 16'
      URU
      GOOOAL!Agustín Álvarez MartínezAssist: J. Trindade
   3. 17'
      PER
      GOOOAL!LiliuAssist: G. Carmona
   4. 33'
      URU
      GOOOAL!F. TorresAssist: D. Terans
   5. 36'
      PER
      Yellow card
      Alfredo Rojas
   6. 42'
      PER
      Yellow card
      J. Valoyes
   7. 45'
      URU
      GOOOAL!G. KagelmacherAssist: J. Trindade
3. 1. Second half
   2. 46'
      PER
      Substitution
      ▲Jarlin Quintero▼M. Velásquez
   3. 53'
      PER
      Yellow card
      O. Barreto
   4. 59'
      URU
      Yellow card
      Walter Gargano
   5. 68'
      PER
      Substitution
      ▲Joazhiño Arroé▼O. Barreto
   6. 69'
      URU
      GOOOAL!D. TeransPenalty
   7. 77'
      URU
      Substitution
      ▲A. Canobbio▼G. González
   8. 78'
      URU
      Substitution
      ▲Pablo Ceppelini▼D. Terans
   9. 80'
      URU
      Substitution
      ▲A. Nahuelpán▼Agustín Álvarez Martínez
   10. 80'
       URU
       GOOOAL!Agustín Álvarez MartínezAssist: A. Canobbio
   11. 82'
       URU
       Substitution
       ▲N. Schiappacasse▼F. Torres
   12. 83'
       URU
       Substitution
       ▲Agustín Álvarez Wallace▼Walter Gargano
   13. 83'
       PER
       Substitution
       ▲R. Huaccha▼Liliu
   14. 83'
       PER
       Substitution
       ▲L. Villar▼Marcio Valverde