Rosario Central beat San Lorenzo 2-0. The winner had to work for it: 2 from 21 shots. Best on the pitch was L. Ferreyra, rated 8.2.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   ARG 4-2-3-1·5-4-1 ARG
   Coach: C. González · D. DaboveReferee: C. Ferreyra📍 Estadio Dr. Lisandro de la Torre
2. 1. First half
   2. 11'
      ARG
      GOOOAL!F. AlmadaAssist: Luciano Ismael Ferreyra
   3. 42'
      ARG
      Yellow card
      A. Diaz
3. 1. Second half
   2. 46'
      ARG
      Substitution
      ▲Angel Romero▼A. Diaz
   3. 46'
      ARG
      Substitution
      ▲J. Ramirez▼F. Flores
   4. 48'
      ARG
      Yellow card
      D. Martinez
   5. 61'
      ARG
      Substitution
      ▲F. Torrent▼D. Martinez
   6. 66'
      ARG
      Substitution
      ▲N. Fernandez▼L. Melano
   7. 66'
      ARG
      Substitution
      ▲A. Donatti▼D. Braghieri
   8. 67'
      ARG
      Substitution
      ▲E. Vecchio▼L. Dupuy
   9. 72'
      ARG
      Substitution
      ▲F. Lo Celso▼L. Ferreyra
   10. 72'
       ARG
       Substitution
       ▲R. Sangiovani▼R. Villagra
   11. 73'
       ARG
       Substitution
       ▲Gino Peruzzi▼V. Salazar
   12. 78'
       ARG
       Yellow card
       R. Sangiovani
   13. 81'
       ARG
       GOOOAL!L. GambaAssist: E. Vecchio