Deportes Tolima and Talleres drew 1-1. Best on the pitch was J. Campaz, rated 8.9.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   COL 4-2-3-1·4-2-3-1 ARG
   Coach: H. Torres · A. MedinaReferee: A. Herrera📍 Estadio Manuel Murillo Toro
2. 1. First half
   2. 8'
      COL
      Yellow card
      Nilson Castrillon
   3. 22'
      ARG
      Yellow card
      N. Tenaglia
   4. 43'
      ARG
      GOOOAL!N. TenagliaAssist: E. Díaz
3. 1. Second half
   2. 54'
      ARG
      Substitution
      ▲F. Mac Allister▼F. Navarro
   3. 55'
      COL
      Substitution
      ▲Daniel Cataño▼L. Miranda
   4. 56'
      COL
      GOOOAL!J. Campaz
   5. 62'
      COL
      Yellow card
      Daniel Cataño
   6. 65'
      COL
      Yellow card
      J. Campaz
   7. 65'
      ARG
      Yellow card
      P. Hincapie
   8. 65'
      COL
      Substitution
      ▲J. Nieto▼J. Ríos
   9. 65'
      COL
      Substitution
      ▲Omar Albornoz▼Andrey Estupinan
   10. 71'
       COL
       Substitution
       ▲Leyvin Balanta▼J. Angulo
   11. 71'
       COL
       Substitution
       ▲G. Ramírez▼J. Ortiz
   12. 76'
       ARG
       Substitution
       ▲Augusto Schott▼N. Tenaglia
   13. 76'
       ARG
       Substitution
       ▲Mateo Retegui▼Michael Santos
   14. 78'
       COL
       Yellow card
       C. Trujillo
   15. 83'
       ARG
       Substitution
       ▲D. Romero▼F. Fragapane
   16. 83'
       ARG
       Substitution
       ▲J. Soñora▼Carlos Auzqui
   17. 85'
       ARG
       Yellow card
       F. Mac Allister