Huachipato beat 12 de Octubre 1-2. Huachipato played with ten from minute 35. W. Mazzantti scored 2 goals. Best on the pitch was W. Mazzantti, rated 8.3.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   PAR 4-4-2·4-3-3 CHI
   Coach: P. Sarabia · J. LuveraReferee: Flavio Rodrigues De Souza📍 Estadio Luís Alfonso Giagni
2. 1. First half
   2. 20'
      CHI
      Yellow card
      B. Gazzolo
   3. 25'
      CHI
      GOOOAL!W. Mazzantti
   4. 35'
      CHI
      Yellow card
      B. Gazzolo
   5. 35'
      CHI
      Red card
      B. Gazzolo
   6. 43'
      PAR
      Yellow card
      F. Manenti
3. 1. Second half
   2. 46'
      PAR
      Substitution
      ▲J. Montiel▼V. Ayala
   3. 47'
      PAR
      Yellow card
      A. Shuartzman
   4. 55'
      PAR
      GOOOAL!A. NúñezAssist: V. Cáceres
   5. 57'
      CHI
      GOOOAL!W. MazzanttiAssist: C. Cuevas
   6. 61'
      PAR
      Substitution
      ▲V. Barrios▼Juan Aguilar
   7. 61'
      PAR
      Substitution
      ▲Diego Ríos▼A. Shuartzman
   8. 61'
      CHI
      Substitution
      ▲A. Castillo▼N. Baeza
   9. 64'
      PAR
      Yellow card
      F. Manenti
   10. 64'
       PAR
       Red card
       F. Manenti
   11. 69'
       CHI
       Substitution
       ▲N. Silva▼W. Mazzantti
   12. 69'
       CHI
       Substitution
       ▲C. Huanca▼J. Altamirano
   13. 73'
       CHI
       Yellow card
       C. Sepúlveda
   14. 73'
       PAR
       Substitution
       ▲J. Marabel▼A. Núñez
   15. 76'
       PAR
       Yellow card
       V. Barrios
   16. 79'
       CHI
       Yellow card
       N. Silva