Rosario Central beat San Lorenzo 1-2. The winner had to work for it: 2 from 23 shots. Best on the pitch was E. Vecchio, rated 8.2.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   ARG 4-2-3-1·4-4-2 ARG
   Coach: L. Romagnoli · C. GonzálezReferee: Bruno Arleu de Araujo📍 Estadio Pedro Bidegaín
2. 1. First half
   2. 24'
      ARG
      Yellow card
      L. Blanco
   3. 25'
      ARG
      Own goalG. Avila
   4. 40'
      ARG
      Yellow card
      Marco Ruben
   5. 44'
      ARG
      Yellow card
      F. Flores
3. 1. Second half
   2. 48'
      ARG
      Yellow card
      F. Gattoni
   3. 54'
      ARG
      Substitution
      ▲A. Diaz▼F. Di Santo
   4. 62'
      ARG
      Substitution
      ▲J. Elias▼J. Ramirez
   5. 65'
      ARG
      Yellow card
      E. Vecchio
   6. 66'
      ARG
      Own goalF. Gattoni
   7. 72'
      ARG
      GOOOAL!E. VecchioAssist: M. Ruben
   8. 73'
      ARG
      Yellow card
      V. Salazar
   9. 75'
      ARG
      Substitution
      ▲F. Troyansky▼Julián Palacios
   10. 75'
       ARG
       Substitution
       ▲M. Peralta▼N. Fernandez
   11. 82'
       ARG
       Substitution
       ▲R. Villagra▼D. Zabala
   12. 87'
       ARG
       Substitution
       ▲F. Torrent▼D. Martinez
   13. 90+2'
       ARG
       Substitution
       ▲R. Sangiovani▼E. Vecchio
   14. 90+2'
       ARG
       Substitution
       ▲A. Marinelli▼L. Gamba