Libertad Asuncion beat Newell's Old Boys 1-0. Newell's Old Boys controlled the ball — 64% possession — but had nothing to show for it. Newell's Old Boys played with ten from minute 90. Best on the pitch was Leonel Vangioni, rated 7.7.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   PAR 4-4-2·3-4-3 ARG
   Coach: D. Garnero · G. BurgosReferee: G. Tejera📍 Estadio Dr. Nicolás Leoz
2. 1. First half
   2. 9'
      PAR
      GOOOAL!S. FerreiraAssist: J. Enciso
3. 1. Second half
   2. 46'
      ARG
      Substitution
      ▲B. Aguirre▼A. Rodríguez
   3. 46'
      ARG
      Substitution
      ▲L. Cingolani▼Justo Giani
   4. 49'
      PAR
      Yellow card
      S. Ferreira
   5. 49'
      ARG
      Yellow card
      M. Orihuela
   6. 51'
      ARG
      Yellow card
      Y. Cabral
   7. 62'
      ARG
      Substitution
      ▲E. Cabrera▼I. Scocco
   8. 62'
      ARG
      Substitution
      ▲Mauro Formica▼Pablo Pérez
   9. 64'
      PAR
      Substitution
      ▲R. Bogarin▼S. Ferreira
   10. 64'
       PAR
       Substitution
       ▲Adrián Martínez▼Julio César Enciso
   11. 65'
       ARG
       Yellow card
       L. Cingolani
   12. 67'
       ARG
       Yellow card
       C. Lema
   13. 77'
       PAR
       Substitution
       ▲B. Cáceres▼P. Delvalle
   14. 79'
       ARG
       Yellow card
       E. Cabrera
   15. 87'
       PAR
       Yellow card
       I. Ramirez
   16. 88'
       ARG
       Substitution
       ▲N. Castro▼Y. Cabral
   17. 89'
       ARG
       Yellow card
       M. Llano
   18. 90'
       ARG
       Yellow card
       L. Cingolani
   19. 90'
       ARG
       Red card
       L. Cingolani