Penarol beat Corinthians 4-0. Agustín Álvarez Martínez scored 3 goals. Best on the pitch was Agustín Álvarez Martínez, rated 9.5.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   URU 4-1-4-1·4-3-3 BRA
   Coach: M. Larriera · Vágner ManciniReferee: N. Pitana📍 Estadio Campeón del Siglo
2. 1. First half
   2. 5'
      URU
      GOOOAL!Agustín Álvarez MartínezAssist: J. Trindade
   3. 9'
      BRA
      Yellow card
      Fábio Santos
   4. 14'
      URU
      GOOOAL!Agustín Álvarez Martínez
   5. 45'
      BRA
      Yellow card
      Camacho
3. 1. Second half
   2. 46'
      BRA
      Substitution
      ▲Rómulo Otero▼Xavier
   3. 49'
      BRA
      Yellow card
      Jô
   4. 53'
      URU
      GOOOAL!A. Canobbio
   5. 57'
      URU
      Yellow card
      J. Piquerez
   6. 61'
      BRA
      Substitution
      ▲Lucas Piton▼Mateus Vital
   7. 61'
      BRA
      Substitution
      ▲Léo Natel▼Jô
   8. 65'
      URU
      Yellow card
      A. Canobbio
   9. 69'
      URU
      GOOOAL!Agustín Álvarez MartínezAssist: P. Ceppelini
   10. 70'
       BRA
       Substitution
       ▲Adson▼Camacho
   11. 74'
       URU
       Substitution
       ▲Damian Musto▼Walter Gargano
   12. 74'
       URU
       Substitution
       ▲N. Schiappacasse▼Agustín Álvarez Martínez
   13. 75'
       URU
       Substitution
       ▲Maxi Pereira▼A. Canobbio
   14. 83'
       URU
       Substitution
       ▲C. Olivera▼F. Torres
   15. 87'
       URU
       Substitution
       ▲Valentín Rodríguez▼G. González