San Lorenzo beat 12 de Octubre 0-2. The winner had to work for it: 2 from 13 shots. Best on the pitch was Óscar Romero, rated 9.6.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   PAR 4-2-3-1·3-1-4-2 ARG
   Coach: P. Sarabia · L. RomagnoliReferee: Rodolpho Toski Marques📍 Estadio Luís Alfonso Giagni
2. 1. First half
   2. 20'
      PAR
      Yellow card
      P. Velázquez
   3. 25'
      PAR
      Yellow card
      J. Ojeda
   4. 34'
      ARG
      Yellow card
      Y. Gordillo
   5. 45'
      ARG
      GOOOAL!A. DiazAssist: Ó. Romero
3. 1. Second half
   2. 58'
      PAR
      Substitution
      ▲V. Barrios▼J. Ojeda
   3. 58'
      PAR
      Substitution
      ▲J. Marabel▼A. Shuartzman
   4. 59'
      ARG
      GOOOAL!Óscar RomeroAssist: Á. Romero
   5. 64'
      ARG
      Substitution
      ▲F. Coloccini▼D. Braghieri
   6. 68'
      PAR
      Substitution
      ▲J. Montiel▼P. Velázquez
   7. 68'
      PAR
      Substitution
      ▲Diego Ríos▼A. Núñez
   8. 69'
      PAR
      Yellow card
      Victor Cáceres
   9. 69'
      ARG
      Substitution
      ▲S. Rosane▼Julián Palacios
   10. 70'
       ARG
       Substitution
       ▲J. Ramirez▼A. Diaz
   11. 79'
       PAR
       Substitution
       ▲J. Brítez▼Juan Aguilar
   12. 85'
       ARG
       Substitution
       ▲Gino Peruzzi▼Nicolás Ezequiel Fernández Mercau
   13. 85'
       ARG
       Substitution
       ▲A. Sabella▼Y. Gordillo
   14. 88'
       PAR
       Yellow card
       Richard Salinas
   15. 90'
       ARG
       Yellow card
       A. Sabella