Independiente beat Guabirá 1-0. The winner had to work for it: 1 from 22 shots. Best on the pitch was L. Romero, rated 8.0.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   ARG 4-3-3·5-3-2 BOL
   Coach: J. Falcioni · V. AndradaReferee: D. López📍 Estadio Libertadores de América
2. 1. First half
   2. 31'
      BOL
      Substitution
      ▲C. Abastoflor▼J. Vogliotti
   3. 45'
      ARG
      Yellow card
      S. Barreto
3. 1. Second half
   2. 61'
      ARG
      Substitution
      ▲Andrés Roa▼S. Palacios
   3. 69'
      BOL
      Yellow card
      Bruno Pascua
   4. 83'
      ARG
      GOOOAL!S. Romero
   5. 85'
      BOL
      Substitution
      ▲C. Góngora▼A. Quiroga
   6. 87'
      ARG
      Yellow card
      S. Sosa
   7. 89'
      ARG
      Substitution
      ▲A. Arregui▼D. Blanco
   8. 90+1'
      ARG
      Substitution
      ▲B. Martinez▼A. Velasco
   9. 90+1'
      ARG
      Substitution
      ▲A. Soñora▼L. Romero