Rosario Central and 12 de Octubre drew 0-0. Rosario Central controlled the ball — 72% possession — but had nothing to show for it. Best on the pitch was G. Avila, rated 8.2.

1. 0'
   ⚽Kick-off
   CONMEBOL Sudamericana 2021
   ARG 4-4-2·4-2-3-1 PAR
   Coach: C. González · P. SarabiaReferee: A. Matonte📍 Estadio Florencio Solá
2. 1. First half
   2. 4'
      ARG
      Yellow card
      D. Martinez
   3. 22'
      ARG
      Substitution
      ▲F. Torrent▼D. Martinez
   4. 31'
      ARG
      Yellow card
      F. Almada
3. 1. Second half
   2. 53'
      PAR
      Yellow card
      F. Manenti
   3. 64'
      PAR
      Substitution
      ▲Diego Ríos▼Juan Aguilar
   4. 64'
      PAR
      Substitution
      ▲J. Brítez▼A. Shuartzman
   5. 64'
      PAR
      Substitution
      ▲V. Barrios▼J. Marabel
   6. 72'
      ARG
      Substitution
      ▲G. Infantino▼L. Ferreyra
   7. 72'
      ARG
      Substitution
      ▲L. Dupuy▼L. Gamba
   8. 78'
      PAR
      Substitution
      ▲P. Velázquez▼A. Núñez
   9. 90'
      PAR
      Yellow card
      Diego Ríos
   10. 90'
       ARG
       Substitution
       ▲A. Marinelli▼D. Zabala